🩺 Nursing Question of the Day

Challenge yourself with one exam-style nursing question every day.

✅ Think carefully • ✅ Choose your answer • ✅ Then scroll down to check the explanation.

🎯 Today’s Challenge

Don’t scroll to the explanation immediately!
First, observe the question carefully, select the answer you believe is correct, and then compare it with the detailed explanation below. This daily practice will strengthen your clinical thinking and improve your performance in NCLEX, NORCET, AIIMS, ESIC, RRB, DSSSB, HAAD, Prometric, and Staff Nurse recruitment exams.

🩸 Graft-versus-Host Disease (GVHD)

✅ Answer: (A) Diffuse skin rash

📖 What is Graft-versus-Host Disease (GVHD)?

Graft = Transplanted donor cells
Host = Recipient (patient)
Disease = Harm caused by the donor immune cells

👉 Graft-versus-Host Disease (GVHD) is a complication that occurs after an allogeneic bone marrow or stem cell transplant, where the donor’s immune cells attack the recipient’s healthy tissues.

🩺 Why is Option (A) Correct?

The earliest and most common sign of acute GVHD is a:

• ✔ Diffuse maculopapular skin rash
• ✔ Usually begins on the palms, soles, face, neck, or trunk
• ✔ May later spread over the entire body

👉 Skin involvement often appears before liver or gastrointestinal symptoms, making a diffuse skin rash the earliest clinical indicator.

❌ Why Other Options Are Wrong?

(B) Bradycardia
❌ Bradycardia is not a characteristic feature of graft-versus-host disease.

(C) Hematuria
❌ Hematuria may occur due to other complications such as hemorrhagic cystitis, but it is not an early sign of GVHD.

(D) Blurred Vision
❌ Blurred vision is not an early manifestation of GVHD. Eye involvement, such as dry eyes, is more commonly seen in chronic GVHD.

📝 Target Organs in Acute GVHD

📌 Exam Tip: The classic organs affected by acute GVHD are the skin, gastrointestinal tract, and liver. In nursing exams, the earliest sign is usually a diffuse maculopapular skin rash, followed by diarrhea and liver dysfunction.